Nitric Oxide Involved in Wound Healing

Nitric oxide sufficiency has been established as an important mechanism responsible for normal healing, a researcher recently pointed out in an analysis of the medical literature.

Studies have shown that nitric oxide (NO) plays a critical role in normal wound healing. Preliminary clinical wound healing studies using wound fluid nitrate determinations as measures of wound NO bioactivity suggest that threshold wound fluid nitrate values may function as an effective diagnostic indicator of successful wound healing.

Wound fluid nitrate determination would identify nitric-oxide-deficiency-related effects on healing that can impact the integrity and efficacy of the wound healing process. With clinical validation, wound fluid nitrate may qualify as a wound healing biomarker and shape subsequent treatment by identifying the NO bioactivity of a wound.

Reference:

Boykin JV, Jr. Wound nitric oxide bioactivity: a promising diagnostic indicator for diabetic foot ulcer management. J Wound Ostomy Continence Nurs. 2010 Jan-Feb;37(1):25-32;33-4.