Resveratrol Supports Heart Health

by CP Staff

A recent study investigated the effect of the potent antioxidant trans-resveratrol on markers of circulatory function. The researchers evaluated flow-mediated dilatation of the brachial artery, which is a measurement of both endothelial function and cardiovascular health by evaluating the dilation of this blood vessel. The endothelium is the thin layer of cells that lines the inside of blood vessels and plays an important role in regulation of the blood flow. Proper endothelial function is required for a healthy heart and blood pressure.

In this new double-blind, randomized, crossover study, researchers evaluated flow-mediated dilation after supplementation with varying dosages of resveratrol in overweight men or post-menopausal women with untreated blood pressure concerns. The subjects received resveratrol at dosages of 30, 90 and 270 mg and a placebo at weekly intervals. One hour after supplementation, the subjects were evaluated for flow mediated dilation and plasma resveratrol levels.

The results showed that resveratrol supplementation increased plasma resveratrol levels and increased flow-mediated dilation with a significant dose-effect, meaning increasing dosages of resveratrol resulted in more significant changes in its plasma levels and dilation of the brachial artery. Flow mediated dilation increased from 4.1 percent with placebo to 7.7 percent with 270 mg dose of resveratrol, which also correlated with plasma resveratrol levels.

The researchers stated, “Acute resveratrol consumption increased plasma resveratrol concentrations and flow-mediated dilation in a dose-related manner. This effect may contribute to the purported cardiovascular health benefits of grapes and red wine.”

Reference:

Wong RH, Howe PR, Buckley JD, Coates AM, Kunz I, Berry NM. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis. 2010 Jul 29. Published Online Ahead of Print.