Nitric Oxide Involved in Bone Health

Nitric oxide (NO) plays a role in bone health in postmenopausal women, researchers have found. Scientists have theorized that declining local NO production secondary to estrogen deficiency in postmenopausal women, and perhaps in older men, could be one of the key reasons for age-related increased incidences of suboptimal heart function and sexual function, as well as less than optimal bone health.

A number of in vitro and in vivo data have revealed the efficacy of nitroglycerin and nitrates on bone cells. Furthermore, the beneficial effects of estrogen on bone health are mediated via the NO-cGMP pathway. Therefore, NO donor therapy is an attractive alternative to estrogen therapy to support bone health. When the body is unable to produce adequate amounts of NO for biological homeostasis, administration of exogenous NO or prolongation of the actions of endogenous NO are practical ways to supplement NO, especially in postmenopausal women.

Given NO’s role in bone health, researchers now believe that supplementation of NO compounds can not only be used to support cardiovascular and sexual function, but they also could be a valuable addition to the armamentarium of therapies for promoting optimal bone health.

Reference:

Wimalawansa SJ. Nitric oxide: novel therapy for osteoporosis. Expert Opin Pharmacother. 2008 Dec;9(17):3025-44.