Keep Your Brain\'s “Network” Like New

In a lot of ways, your brain is like a computer: Just a single kink in the hard drive can cause any number of essential operations to run slower, with access to your memory files moving at a crawl until, eventually, the entire system comes crashing down.

Unlike computers, however, a new brain isn’t the only solution when things start to go haywire. In fact, research shows that a little routine maintenance of your neurological “network” may be all it takes to keep your body’s precious information systems intact for years to come.

Science has discovered that your brain’s most common sources of disruption are the distinct physical changes—namely, protein deposits and tangles—which can emerge as a result of age, imbalanced inflammatory responses and oxidative stress. These deposits and tangles can alter neuron communication and nerve transmission, interfering with memories, thoughts, feelings, and more.¹

Obviously, any strategy that can stave off these physical changes will help to keep your mind working like a well-oiled machine well into old age. And when it comes to supporting cognitive health, you won’t find a fiercer ally than curcumin.

Evidence suggests that this Indian spice may offer critical benefits to your brain—especially by slowing the accumulation of precursor protein deposits and neurofibrillary tangles that lead to some forms of age-related cognitive decline .^2-3 Studies also indicate that curcumin’s powerful antioxidant properties can help to balance inflammatory responses in the brain.^4-7 Unfortunately, however, its poor absorption from dietary sources means that your body would have a hard time sustaining levels that could deliver any significant impact… until now, that is.^8-9

Researchers have recently patented a new, highly bioavailable, optimized form of curcumin called Longvida®, which not only enters the bloodstream in significant quantities, but is also able to cross the blood-brain barrier with greater efficiency than any other curcumin product on the market.

Green tea is another potential source of neuroprotection, with research in animals suggesting that its active component EGCG can enhance memory and modulate enzymatic processes that sustain brain health.¹⁰ EGCG is also a powerful antioxidant, with cell-based studies supporting its ability to stimulate glutathione synthesis in the brain, thereby guarding neurons against the effects of oxidative stress.¹¹

Vitamin D is equally essential to brain health, with reviews suggesting a potential link between low levels of this “sunshine” vitamin and low cognitive test scores, as well as suboptimal brain and vascular health.^12-13 Meanwhile, nicotinamide (a form of vitamin B3) has been shown to lower levels of the protein deposits implicated in tangle formation, while reinforcing the networks through which neurons communicate information.¹⁴ Finally, animal research trials show that the proteolytic enzyme serrapeptase is able to ensure optimal inflammatory balance and blood flow—which means that your brain will get the oxygen and nutrient support that it needs to function at its peak.¹⁵

You’ll find all the ingredients above combined with Longvida in CP’s daily brain formula MemoRx™—designed to furnish your brain with comprehensive cognitive support.

References:

1. Grady CL, Furey ML, Pietrini P, Horwitz B, Rapoport SI. Altered brain functional connectivity and impaired short-term memory in Alzheimer’s disease. Brain. 2001;124(4):739-56.

2. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1;21(21):8370-7.

3. Zhang C, Browne A, Child d, Tanzi RE. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem. 2010 Sep 10:285(37):28472-80.

4. Begum AN, Jones MR, Lim GP, et al. Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease. J Pharmacol Exper Thera. 2008;326(1):196-208.

5. Frautschy, SA. 38th Annual Meeting of the Society of Neuroscience , Washington DC, November 15, 2008.

6. Goel A, Kunnumakkara AB, Aggarwal BB. Biochem Pharmacol. 2008 Feb 15;75(4):787-809.

7. Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG. J Ag Food Chem Submitted 2009.

8. Frautschy SA, et al. Efficacy of curcumin formulations in relation to systemic availability in the brain and different blood compartments in neuroinflammatory and AD models, at the 39th Annual Meeting of the Society of Neuroscience, Chicago, October 2009.

9. Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J. Agric Food Chem 2010. 58(4):2095

10. Lee JW, Lee YK, Ban JO, Ha TY, Yun YP, Han SB, Oh KW, Hong JT.Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice. J Nutr. 2009 Oct;139(10):1987-93.

11. Kim CY, Lee C, Park GH, Jang JH. Neuroprotective effect of epigallocatechin-3-gallate against beta-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity. as an enhanced supplement for huperzine A to treat Alzheimer’s disease. Arch Pharm Res. 2009 Jun;32(6):869-81.

12. Pogge E.Vitamin D and Alzheimer’s disease: is there a link? Consult Pharm. 2010 Jul;25(7):440-50.

13. Buell JS, Dawson-Hughes B, Scott TM, Weiner DE, Dallal GE, Qui WQ, Bergethon P, Rosenberg IH, Folstein MF, Patz S, Bhadelia RA, Tucker KL. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology 2010 Jan 5;74(1):18-26.

14. Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM Nicotinamide Restores Cognition in Alzheimer’s Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau. Journal of Neuroscience. 2008;28(45):11500-11510.

15. Viswanatha Swamy AH, Patil PA. Effect of some clinically used proteolytic enzymes on inflammation in rats. Indian J Pharm Sci. 2008 Jan;70(1):114-7.