Joint Comfort Modulated by Chondroitin Sulfate

Chondroitin sulfate supports joint function in the hand, according to a new study. Chondroitin sulfate is a glycosaminoglycan (GAG) composed of chains of alternating sugars, and is generally found attached to proteins as part of a proteoglycan. Chondroitin sulfate is an important structural component of cartilage and provides resistance to compression in joints.

In this randomized, placebo-controlled, double-blind clinical trial, 162 subjects with suboptimal joint health in the hand confirmed by x-ray and who also had comfort and flexibility issues were evaluated. The subjects received 800 mg of chondroitin sulfate per day or placebo for 6 months duration. The subjects were assessed for hand comfort with hand function, grip strength, morning stiffness, and medication intake for hand discomfort at the beginning of the study and again after 6 months.

The study found that in the subjects who received chondroitin sulfate, the level of comfort in the hand and hand function was significantly enhanced after 6 months of supplementation compared to the placebo group. Furthermore, the chondroitin sulfate group reported a shorter duration of morning stiffness and greater overall efficacy compared to the placebo group. There was no difference in safety, medication intake, and grip strength between the two groups.

The study authors concluded that chondroitin sulfate safely enhanced hand function and comfort in individuals concerned about joint health.

Reference:

Gabay C, Medinger-Sadowski C, Gascon D, Kolo F, Finckh A. Symptomatic effect of chondroitin sulfate 4&6 in hand osteoarthritis the finger osteoarthritis chondroitin treatment study (FACTS). Arthritis Rheum. 2011 Sep 6. Published Online Ahead of Print.