Free Radicals Play Important Role in Arterial Health

by Jeffrey H. Reinhardt, MSc

Decreased arterial compliance and flexibility are now known to be caused by an oxidative stress-mediated process triggered by prolonged exposure to excess concentrations of reactive oxygen species (ROS) in the blood. A progressive cascade of unquenched free radical species and damaging cytokines initiates changes that can affect the cells lining the arteries (the endothelium) and lead to changes in cardiovascular health and function.

These highly reactive molecules are produced by the accumulation of circulating monocytes that have been recruited to the dysfunctional areas of the endothelial cells lining the affected arteries. Over time, the cumulative increase in the extent of the free radical-induced damage to the epithelial cells lining the arterial walls attracts more monocytes from the blood. As stated above, these newly congregating monocytes adhere to the endothelium and then penetrate into the arterial wall where they continue to differentiate into new macrophages, which phagocytose or engulf even more fat from the blood to add to the burden of cell accumulation. This makes the involved artery less flexible, which progressively affects circulation to the tissues and organs.

These progressive arterial thickenings affect the lining of the arteries and continue to generate a growing cascade of free radicals and damaging cytokines, which produce more extensive, widespread thickening that creates suboptimal arterial and heart health. Thus, the effect that the uninterrupted cytokine and ROS have on the endothelial lining of the arteries produces a continuous, cascading cycle that affects the linings of the arteries, which leads to the progressive decrease in arterial health and compliance.

To help slow down this cascade of reactive oxygen species and support endothelium health, three capsules per day of the newly reformulated Complete Antioxidant (available after November 15) provides a broad spectrum of fat and water soluble antioxidants that act together to trap the excess free radicals. The addition of (R)-lipoic acid will support optimal endothelial cell health and enhance the benefits of N-acetyl cysteine (NAC) provided by Complete Antioxidant. NAC promotes the production of glutathione, one of the most effective, water soluble antioxidants.

CoQ10-H2™ (ubiquinol) is the second generation, reduced form of coenzyme Q10. It is more bioavailable than oral supplementation with the oxidized, first generation CoQ10, called ubidecarone. CoQ10-H2 is also a superior fat soluble antioxidant that helps to minimize the formation of oxidized LDL.

Lipid Control®, in combination with a wholesome, nutritious diet, helps maintain healthy cholesterol levels in the blood, thus also supporting arterial wall health.